What are the big questions in Psychiatry?

Confronted with the challenge to do a Thought Leader presentation on 10th July, I have been thinking about the Big Questions in Psychiatry, and would welcome your input.

Some thoughts that come to mind:

1. Is the current classification of psychiatric disorders useful in psychiatric practice? What might be a more useful classification system?
   
2. In our enthusiasm for newer drugs, have been abandoned the more effective antidepressants?
3. Are the second generation antipsychotics really an advance, or are they merely draining our mental health budget?
4. Can we prevent or reduce the burden of mental illness in future generations by massively intervening in our schools?
5. Is therapy through the internet the wave of the future?

I would welcome your input into these and other questions you might raise.

Perminder